Moreover, plasma leptin concentrations were directly correlated to BMI in all the groups studied, while a negative correlation between leptin and rT 3 was detectable in group C (r = –0.44, p < 0.05), also after adjusting for BMI and sex. Females also showed higher plasma leptin levels than males in the controls, group A and group B, but not in group C.
Euthyroid sick syndrome (ESS) is usually associated with the disease severity and deterioration prognosis in critical illness. However, it is not clear whether the thyroid gland is impaired in COVID-19 patients. The patients of group C showed lower plasma leptin levels than the controls, 6.6 (5.5–14.2) and 16.3 (7.2–23.7) ng/ml (median with interquartile range in parentheses, p < 0.05), respectively. BackgroundCoronavirus disease 2019 (COVID-19) has been shown to affect almost every organ throughout the body. Results: The data on thyroid hormones enabled us to identify three groups: group A, subjects (15 patients) with T 3 and fT 3 levels comparable to those of controls group B, subjects (25 patients) with T 3 and fT 3 levels lower than controls and rT 3 levels comparable to those of controls group C, subjects (24 patients) with T 3 and fT 3 levels lower than those of controls and high rT 3 levels.
Nutritional status was also evaluated in all subjects studied by the measurement of body mass index (BMI), lymphocytes, serum iron, hemoglobin, plasma albumin, transferrin and total cholesterol. Many conditions result in increases or decreases in serum total thyroxine (T4) and triiodothyronine (T3) concentrations, associated with normal thyroid-stimulating hormone (TSH) concentrations and no symptoms or signs of thyroid dysfunction.
#EUTHYROID SICK SYNDROME FREE#
In all subjects tri-iodothyronine (T 3), thyroxine (T 4), reverse T 3 (rT 3), free T 3 (fT 3), free T 4 (fT 4), TSH, and plasma leptin concentrations were measured. Methods: Sixty-four NTI elderly patients (75.0 ± 6.3 years, 27 males and 37 females) and 21 age- and sex-matched healthy controls (73.0 ± 5.5 years, 9 males and 12 females) were enrolled in the study. Treatment is directed toward the underlying illness thyroid hormone replacement is not indicated. Diagnosis is based on excluding hypothyroidism. The euthyroid sick syndrome appears to be a complex mix of physiologic adaptation and pathologic response to acute illness. Objective: To evaluate plasma leptin concentrations and thyroid function in elderly patients with nonthyroidal illnesses (NTI). Euthyroid sick syndrome is a condition in which serum levels of thyroid hormones are low in patients who have nonthyroidal systemic illness but who are actually euthyroid. Background: Leptin, the ob gene product, seems to be involved in regulating energy expenditure in humans, but its role in the pathophysiology of the energy imbalance in chronically ill patients is largely unknown.
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